Recent patents on drug delivery & formulation 2010-01-01

Properties and clinical development of a novel coating technology: the poly[bis(trifluoroethoxy)phosphazene].

Davide Capodanno, Corrado Tamburino

文献索引：Recent Pat. Drug Deliv. Formul. 4(1) , 18-22, (2010)

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摘要

Ultrapure poly[bis(trifluoroethoxy)phosphazene] is a novel biocompatible, anti-inflammatory, antithrombogenic polymer which has the potential to cover stent devices without elution of a cell cycle inhibiting drug. The properties of polyphosphazene are likely to extend its use to a broad array of promising applications. This article reviews the features of the polymer and some recent patents related to use of poly[bis(trifluoroethoxy)phosphazene] in coating, its relevance as compared to other polymers, current evidence on pre-clinical and clinical performance, and future perspectives.