Bioorganic & medicinal chemistry letters

Synthesis of radiolabeled cytarabine conjugates

P Lagisetty, P Vilekar, V Awasthi

文献索引：Lagisetty, Pallavi; Vilekar, Prachi; Awasthi, Vibhudutta Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4764 - 4767

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被引用次数: 9

摘要

N4-Modified, novel Ara-C conjugate capable of radiolabeling with gamma ray-emitting (99mTc) as well as positron emitting (18F) radionuclides, that is, N4-hydrazine derivative was synthesized. The radiolabeling of N4-(hydrazinonicotinyl)-1-β-arabinofuranosyl cytosine (HAra-C) with 99mTc was performed with over 95% labeling yield. To label HAra-C with 18F, 4-fluoro (18F)-benzaldehyde was synthesized from 4-formyl-N, N, N- ...