Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

ME Safdy, E Kurchacova, RN Schut…

文献索引：Safdy, Max E.; Kurchacova, Elva; Schut, Robert N.; Vidrio, Horacio; Hong, Enrique Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 723 - 730

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被引用次数: 27

摘要

A series of tryptophan analogues having the carboxyl function at the p position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.