Tetrahedron Letters

The accelerated preparation of 1, 4-dihydropyridines using microflow reactors

PT Baraldi, T Noel, Q Wang, V Hessel

文献索引：Baraldi, Patricia Tambarussi; Noel, Timothy; Wang, Qi; Hessel, Volker Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2090 - 2092

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被引用次数: 9

摘要

Abstract The synthesis of 1, 4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1, 4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 ...