Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1, 2, 3-thiadiazole-5- carboxaldoxime (1, pK,= 7.6), 2-methyl-1, 3, 4-thiadiazole-5-carboxaldoxime (2, pK,= 8.4), and 3-methyl-1, 2, 4-thiadiazole-5-carboxaldoxime (3, pK,= 7.0) were prepared in yields of 56, 24, and 58%, respectively, by nitrosation of the corresponding methyl derivatives with ...
