Nonenzymatic cleavages of peptide chains at the cysteine and serine residues through their conversion into dehydroalanine. I. Hydrolytic and oxidative cleavage of …

A Patchornik, M Sokolovsky

文献索引：Sokolovsky,M. et al. Journal of the American Chemical Society, 1964 , vol. 86, p. 1212 - 1217

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被引用次数: 89

摘要

In connection with the specific chemical fragmentation of peptides and proteins, the conditions for the cleavage of dehydroalanine residues, which can be formed from cysteine and serine residues, was investigated. Dehydroalanine residues are cleaved hydrolytically at the SC, bond with nearly quantitative yield by heating the compound to 100'at pH 2 for 1 hr. The cleavage can be facilitated by oxidative activation of the molecule. Oxidation by ...