Synthetic communications

O-Demethylation of opioid derivatives with methane sulfonic acid/methionine: application to the synthesis of naloxone and analogues

JD Andre, JR Dormoy, A Heymes

文献索引：Synthetic Communications, , vol. 22, # 16 p. 2313 - 2327

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被引用次数: 16

摘要

Page 1. SYNTHETIC COMMUNICATIONS, 22(16), 2313-2327 (1992) ... 14 76 C 13 d 15 e C 16 73 C 17 73 B 18 69 C 19 f ... HC1 6N (5mL, 30mmol) added at 50°C. The hydrochloride crystallizes at -10°C. Yield: 4.83g (87%); assay 99.9% 22 (HPLC); [all, -179" ( ~ ~ 2 . 5 , H,O). ...