Development of a scalable synthesis of GSK183390A, a PPAR α/γ agonist

LM Oh, H Wang, SC Shilcrat…

文献索引：Organic Process Research and Development, , vol. 11, # 6 p. 1032 - 1042

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被引用次数: 13

摘要

... It was found that temperature control was again critical in this process. ... The organic layer containing pyrazole 5 was then concentrated and diluted with THF, and the hydrolysis to pyrazole acid ... This procedure was scaled up in the pilot plant to deliver a total of 28.1 kg of pyrazole ...