Click chemistry inspired facile synthesis and bioevaluation of novel triazolyl analogs of Ludartin

…, KA Bhat, R Majeed, A Hamid, MA Khuroo

文献索引：Lone, Shabir H.; Bhat, Khursheed A.; Majeed, Rabiya; Hamid, Abid; Khuroo, Mohd A. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1047 - 1051

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被引用次数: 13

摘要

Abstract A convenient and modular synthesis involving diastereoselective Michael addition followed by regioselective Huisgen 1, 3-dipolar cycloaddition reaction was carried out to furnish 1, 4-disubstituted-1, 2, 3-triazoles of Ludartin. This reaction scheme involving Michael addition followed by regioselective Huisgen 1, 3-dipolar cycloaddition reaction leading to the formation of triazolyl analogs is being reported for the first time. All the ...