Bioorganic & Medicinal Chemistry Letters 2002-12-02

Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent.

J Brad Shotwell, Brian Koh, Hui Won Choi, John L Wood, Craig M Crews

文献索引：Bioorg. Med. Chem. Lett. 12(23) , 3463-6, (2002)

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摘要

A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of any relevant cellular target.