3, 3-Diphenyl-3-(2-alkyl-1, 3, 4-oxadiazol-5-yl) propylcycloalkylamines, a novel series of antidiarrheal agents

GW Adelstein, CH Yen, EZ Dajani…

文献索引：Adelstein,G.W. et al. Journal of Medicinal Chemistry, 1976 , vol. 19, p. 1221 - 1225

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被引用次数: 100

摘要

Discussion No significant antipropulsive or analgesic activity was seen for the unsubstituted monocyclic amines (3a-d, 5a-d) whether or not the oxadiazole ring was present (Table IV). The most potent compounds were the 4-disubstituted piperidines (5e, f); however, the analgesic activity of these compounds was also enhanced with respect to 1 and 2. The bicyclic amines (5g, j), however, show good separation of analgesic and antipropulsive ...