Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure–activity

…, DL Harris, S Dhungana, R Snyder, SP Runyon

文献索引：Zhang, Yanyan; Maitra, Rangan; Harris, Danni L.; Dhungana, Suraj; Snyder, Rodney; Runyon, Scott P. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 2992 - 2997

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被引用次数: 10

摘要

Abstract Apelin peptides function as endogenous ligands of the APJ receptor and have been implicated in a number of important biological processes. While several apelinergic peptides have been reported, apelin-13 (Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe) remains the most commonly studied and reported ligand of APJ. This study examines the effect of C-terminal peptide truncations and comprehensive structure–activity relationship ( ...