Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and …

M Nazaré, DW Will, H Matter, H Schreuder…

文献索引：Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525

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被引用次数: 68

摘要

... Journal of Medicinal Chemistry. ... 2. Chemistry. We first set out to systematically probe the influence on fXa activity of a diverse set of simple substituents on the indole nucleus. The biarylic P1 ligand and the isopropylpiperidine ...