Synthesis and cytotoxicity of 1, 6, 7, 8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with …

…, TS Wu, JJ Chang, D Lednicer, KD Paull…

文献索引：Kuo; Lee; Juang; Lin; Wu; Chang; Lednicer; Paull; Hamel Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1146 - 1156

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被引用次数: 238

摘要

A series of 1, 6, 7, 8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents (eg F, C1, and OCH3 at C-6,(2-7, and C-8 show, in general, potent cytotoxicity against human lung carcinoma (A-549), ileocecal carcinoma (HCT-8), melanoma (RPMI- ...