Tetrahedron letters

Use of CaH 2 as a reductive hydride source: reduction of ketones and imines with CaH 2/ZnX 2 in the presence of a Lewis acid

T Aida, N Kuboki, K Kato, W Uchikawa, C Matsuno…

文献索引：Aida, Toshio; Kuboki, Norikatsu; Kato, Kenji; Uchikawa, Wataru; Matsuno, Chikashi; Okamoto, Sentaro Tetrahedron Letters, 2005 , vol. 46, # 10 p. 1667 - 1669

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被引用次数: 19

摘要

A new combination reagent of CaH 2 /ZnX 2 effectively reduced a variety of ketones and imines to the corresponding alcohols and amines, respectively, in the presence of a catalytic amount of a Lewis acid such as Ti(O-i-Pr) 4 , Al(O-i-Pr) 3 , B(O-i-Pr) 3 and ZnF 2 . ... A reagent combination of CaH 2 /ZnX 2 effectively reduced ketones and imines in the presence of a Lewis acid. ... Reduction with metal hydride reagents has been widely utilized as a routine protocol in organic ...