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Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl) acetamido] thio-4H-1, 2, 4-triazole derivatives

G Turan-Zitouni, ZA Kaplancıklı, MT Yıldız…

文献索引:Turan-Zitouni, Guelhan; Kaplancikli, Zafer Asim; Yildiz, Mehmet Taha; Chevallet, Pierre; Kaya, Demet European Journal of Medicinal Chemistry, 2005 , vol. 40, # 6 p. 607 - 613

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被引用次数: 217

摘要

The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this purpose, new thiazole derivatives of triazoles were synthesized and evaluated for antifungal and antibacterial activity. The reaction of propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the ...