前往化源商城

Journal of Neuroimmunology 2009-08-18

Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis.

Walter Royal, Younus Mia, Huifen Li, Kerry Naunton

文献索引:J. Neuroimmunol. 213(1-2) , 135-41, (2009)

全文:HTML全文

摘要

Vitamin D has been associated with a decreased risk of multiple sclerosis (MS). In this study, serum 1, 25-dihydroxyvitamin D (1, 25-(OH)2 vitD) and 25-hydroxyvitamin D (25-OH vitD), regulatory T cell percentages and naïve and memory T helper cell subsets were measured in 26 patients with multiple sclerosis, 21 who were not on treatment with disease modifying therapy. These studies showed an inverse correlation between 25-OH vitD levels and Treg cell percentages and a direct correlation between Treg cell percentages and 1, 25-(OH)2 vitD:25-OH vitD ratios. In addition, 25-OH vitD levels correlated directly and 1, 25-(OH)2 vitD:25-OH vitD ratios correlated inversely with CXCR3+ naïve T helper cell percentages and CXCR3+naïve:CXCR3+ memory T helper cell ratios. All together, these data demonstrate that vitamin D measurements can reflect measures of immune status among patients with MS.

相关化合物

结构式 名称/CAS号 全部文献
司骨化醇 结构式 司骨化醇
CAS:55721-11-4