Journal of Organic Chemistry 2009-04-03

Total synthesis of psoralidin, an anticancer natural product.

Pallab Pahari, Jürgen Rohr

文献索引：J. Org. Chem. 74(7) , 2750-4, (2009)

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摘要

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.