Chemical Communications 2008-12-21

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives.

Cheng Huang, Yuan Fu, Hua Fu, Yuyang Jiang, Yufen Zhao

文献索引：Chem. Commun. (Camb.) (47) , 6333-5, (2008)

全文：HTML全文

摘要

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.