Preparation of aryl isothiocyanates via protected phenylthiocarbamates and application to the synthesis of caffeic acid (4-isothiocyanato) phenyl ester

X Zhang, YK Lee, JA Kelley…

文献索引：Zhang, Xuechun; Lee, Young K.; Kelley, James A.; Burke Jr., Terrence R. Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 6237 - 6240

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被引用次数: 23

摘要

Isothiocyanates have been widely used in organic synthesis, especially in the synthesis of heterocycles, 1, 2 and they have also been isolated from natural products, including marine sesquiterpenes. 3, 4 Additionally, synthetic isothiocyanates have been reported to exhibit interesting biological effects, among which are antitumor and antiparasitic activities5, 6 and the preparation of irreversible inhibitors. 7 There are currently several methods of ...