A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity

H Huang, Q Chen, X Ku, L Meng, L Lin…

文献索引：Journal of Medicinal Chemistry, , vol. 53, # 8 p. 3048 - 3064

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被引用次数: 113

摘要

... Journal of Medicinal Chemistry. ... However, the therapeutic potential of 3-AP was limited by its poor water solubility and toxicity profile.(17) Therefore, there is increasing interest in structural modification of TSC derivatives with the aim of improving the pharmaceutical profile of ...