Journal of Ethnopharmacology 2005-05-13

Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity.

Sam Medhat Salah, Anna Katharina Jäger

文献索引：J. Ethnopharmacol. 99(1) , 145-6, (2005)

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摘要

An ethyl acetate extract of Artemisia herba-alba was partitioned by HPLC in 10 fractions that were tested in the [(3)H]-flumazenil radioligand assay, for affinity to the GABA(A)-benzodiazepine receptor. Two fractions showed activity from which hispidulin and cirsilineol were isolated. The structures were confirmed by (1)H NMR. The IC(50) values were 8 microM for hispidulin and 100 microM for cirsilineol.