Langmuir 2012-11-13

Lipid rearrangement in DSPC/DMPC bilayers: a neutron reflectometry study.

Yuri Gerelli, Lionel Porcar, Giovanna Fragneto

文献索引：Langmuir 28(45) , 15922-8, (2012)

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摘要

Lipid translocation in membranes is still far from being understood and well characterized for natural cell membranes as well as for simpler bilayer model systems. Several discrepancies with respect to its occurrence and its characteristic time scale are present in the literature. In the current work, the structural changes induced by lipid rearrangement in a distearoyl-/dimyristoyl-phosphocholine binary lipid system have been addressed by means of neutron reflectivity. It has been shown that a fast, spontaneous compositional reorganization with lipid transfer between the two leaflets of the bilayer takes place only when the lipid species are both in the fluid phase. This process has been identified as the so-called lipid flip-flop. Moreover, the influence of the preparation protocol on the structural properties of the system has been investigated.