Tetrahedron letters

Synthesis of diarylmethane derivatives from Pd-catalyzed cross-coupling reactions of benzylic halides with arylboronic acids

SM Nobre, AL Monteiro

文献索引：Nobre, Sabrina M.; Monteiro, Adriano L. Tetrahedron Letters, 2004 , vol. 45, # 44 p. 8225 - 8228

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被引用次数: 103

摘要

A simple catalyst precursor prepared in situ from palladium acetate and triphenylphosphine shows high activity for the Suzuki cross-coupling reaction of benzylic bromides and chlorides with aryl boronic acids. The reaction can be carried out at low catalyst loading (0.002–1mol%) and under mild conditions (room temperature to 80° C) furnishing diarylmethane derivatives in high yields (86–99%).