Therapie 1990-01-01

[Fever caused by fipexide. Evaluation of the national pharmacovigilance survey].

C Guy, N Blay, H Rousset, V Fardeau, M Ollagnier

文献索引：Therapie. 45(5) , 429-31, (1990)

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摘要

Fourteen cases of drug fever due to fipexide were reported by a retrospective survey of a National Network of French Pharmacovigilance. 8 women, 6 men (mean age, 52 years), presented a sudden fever with a mean onset delay of 7 days after the first cure (range 2-12 days). In five cases, drug fever was the only manifestation; in other cases, it was associated with systemic or cutaneous signs. Eosinophilia was frequent (8 cases) and once, a chest picture showed an interstitial pneumonitis. Fever disappeared promptly after discontinuation of the drug and for ten patients, the rechallenge was positive within a short time. The clinical picture and laboratory tests are discussed and suggest an hypersensitivity reaction.