Synthesis and antiproliferative activity of benzofuran-based analogs of cercosporamide against non-small cell lung cancer cell lines

MA Bazin, L Bodero, C Tomasoni, B Rousseau…

文献索引：Bazin, Marc-Antoine; Bodero, Lizeth; Tomasoni, Christophe; Rousseau, Benedicte; Roussakis, Christos; Marchand, Pascal European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 823 - 832

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被引用次数: 16

摘要

Abstract A novel series of 3-methyl-1-benzofuran derivatives were synthesized and screened in vitro for their antiproliferative activity against two human NSCLC cell lines (NSCLC-N6 mutant p53 and A549 wild type p53). Most promising compounds presented a structural analogy with the west part of cercosporamide, a natural product of biological interest. In particular, compounds 10, 12 and 31 showed cytotoxic activities at micromolar ...