Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents

SS Karki, K Panjamurthy, S Kumar, M Nambiar…

文献索引：Karki, Subhas S.; Panjamurthy, Kuppusamy; Kumar, Sujeet; Nambiar, Mridula; Ramareddy, Sureshbabu A.; Chiruvella, Kishore K.; Raghavan, Sathees C. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2109 - 2116

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被引用次数: 58

摘要

Levamisole, the imidazo [2, 1-b] thiazole derivative has been reported as a potential antitumor agent. In the present study, we synthesized, characterized and evaluated biological activity of its novel analogues with substitution in the aralkyl group and on imidazothiadiazole molecules with same chemical backbone but different side chains namely 2-aralkyl-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazoles (SCR1), 2- ...