Tetrahedron Letters

Direct functionalization of labile alkoxyamines

P Brémond, K Kabytaev, SRA Marque

文献索引：Bremond, Paul; Kabytaev, Kuanysh; Marque, Sylvain R.A. Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4543 - 4547

全文：HTML全文

被引用次数: 4

摘要

Direct esterification of a labile alkoxyamine R1R2NOR3, which was previously reported as unsuccessful, is achieved by a Mitsunobu reaction or a nucleophilic substitution. Ester derivatives are obtained under smooth conditions and easily purified. Macrocyclization attempts on ester derivatives were successful for five-membered ring lactones and unsuccessful for 13-membered ring lactones. Moreover, the success of the cyclization was ...