Bioorganic & Medicinal Chemistry Letters 2006-06-01

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

Jay P Powers, Shyun Li, Juan C Jaen, Jinqian Liu, Nigel P C Walker, Zhulun Wang, Holger Wesche

文献索引：Bioorg. Med. Chem. Lett. 16 , 2842-2845, (2006)

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摘要

High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.