A scalable synthesis of a 1, 7-naphthyridine derivative, a PDE-4 inhibitor

X Jiang, GT Lee, EB Villhauer, K Prasad…

文献索引：Organic Process Research and Development, , vol. 14, # 4 p. 883 - 889

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被引用次数: 15

摘要

... Organic Process Research & Development. ... 14 under Ritter reaction conditions(11) using tert-butyl alcohol and sulfuric acid following a literature procedure.(9) As ... In the final process, compound 19 and 10 equiv of phosphorus oxychloride were dissolved in toluene and heated ...