Journal of Microbiology and Biotechnology 2007-03-01

Biosynthesis of bile acids in a variety of marine bacterial taxa.

Dockyu Kim, Jong Suk Lee, Jiyoung Kim, So-Jung Kang, Jung-Hoon Yoon, Won Gon Kim, Choong Hwan Lee

文献索引：J. Microbiol. Biotechnol. 17(3) , 403-7, (2007)

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摘要

Several marine bacterial strains, which were isolated from seawater off the island Dokdo, Korea, were screened to find new bioactive compounds such as antibiotics. Among them, Donghaeana dokdonensis strain DSW-6 was found to produce antibacterial agents, and the agents were then purified and analyzed by LC-MS/MS and 1D- and 2D-NMR spectrometries. The bioactive compounds were successfully identified as cholic acid and glycine-conjugated glycocholic acid, the 7alpha-dehydroxylated derivatives (deoxycholic acid and glycodeoxycholic acid) of which were also detected in relatively small amounts. Other masine isolates, taxonomically different from DSW-6, were also able to produce the compounds in a quite different production ratio from DSW-6. As far as we are aware of, these bile acids are produced by specific members of the genus Streptomyces and Myroides, and thought to be general secondary metabolites produced by a variety of bacterial taxa that are widely distributed in the sea.