Organic Letters

Palladium-catalyzed (Ullmann-Type) homocoupling of aryl halides: A convenient and general synthesis of symmetrical biaryls via inter-and intramolecular …

DD Hennings, T Iwama, VH Rawal

文献索引：Hennings, D. David; Iwama, Tetsuo; Rawal, Viresh H. Organic Letters, 1999 , vol. 1, # 8 p. 1205 - 1208

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被引用次数: 156

摘要

A convenient new procedure is described for both inter-and intramolecular homocoupling of aryl halides (Ullmann reaction) using catalytic palladium in the presence of hydroquinone, a homogeneous reductant. Optimal conditions for the reductive coupling include the use of a 1: 1 molar ratio of Pd (OAc) 2 and As (o-tolyl) 3 in catalytic amounts under basic conditions.