3-(5-)-Amino-o-diarylisoxazoles: Regioselective synthesis and antitubulin activity
DV Tsyganov, VN Khrustalev, LD Konyushkin…
文献索引：Tsyganov, Dmitry V.; Khrustalev, Victor N.; Konyushkin, Leonid D.; Raihstat, Mikhail M.; Firgang, Sergei I.; Semenov, Roman V.; Kiselyov, Alex S.; Semenova, Marina N.; Semenov, Victor V. European Journal of Medicinal Chemistry, 2014 , vol. 73, p. 112 - 125
Abstract A regioselective synthesis of both 5-amino-and 3-aminodiarylisoxazoles substituted with polyalkoxyaryl pharmacophores has been validated. Starting materials for the synthetic scheme were easily available from plant extracts. The targeted molecules were further tested in the phenotypic sea urchin embryo assay to identify compounds with antimitotic microtubule destabilizing activity. Structure–activity relationship studies suggested that the ...
