Tetrahedron

Monoligated Pd (0)-catalyzed intramolecular ortho-and para-arylation of phenols for the synthesis of aporphine alkaloids. Synthesis of (−)-lirinine

M Hellal, S Singh, GD Cuny

文献索引：Hellal, Malik; Singh, Shambhavi; Cuny, Gregory D. Tetrahedron, 2012 , vol. 68, # 6 p. 1674 - 1681

全文：HTML全文

被引用次数: 11

摘要

An intramolecular palladium (0)-mediated ortho-arylation of phenols applied to the synthesis of various substituted aporphines is reported. Most significantly, the efficiency of the transformation was enhanced by the use of monoligated Pd (0) complexes. This methodology was extended to para-arylation of phenols and employed in the synthesis of the aporphine alkaloid (−)-lirinine.