Exploiting the chromone scaffold for the development of inhibitors of corticosteroid biosynthesis

…, F Belluti, A Rampa, RW Hartmann, A Bisi

文献索引：Gobbi, Silvia; Zimmer, Christina; Belluti, Federica; Rampa, Angela; Hartmann, Rolf W.; Recanatini, Maurizio; Bisi, Alessandra Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5347 - 5351

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被引用次数: 2

摘要

The inhibition of corticosteroid biosynthesis could be considered as an emerging strategy to reduce their abnormally high levels, and in this framework CYP11B1 and CYP11B2 represent the most promising targets. In continuing our studies on flavonoid-like scaffolds as privileged structures in medicinal chemistry, in this paper we describe a small library of pyridyl-and imidazolylmethylchromones as potential inhibitors of these enzymes. Testing ...