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Journal of the American Chemical Society

The Preparation of 3-Halo-4-dialkylaminoalkylaminoquinoline Derivatives

AR Surrey, RA Cutler

文献索引:Surrey; Cutler Journal of the American Chemical Society, 1946 , vol. 68, p. 2570,2573

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被引用次数: 15

摘要

The p; esent paper deals with the synthesis of several 3-halo-4-aminoquinoline derivatives as part of a general studylJ on the effect of the position of halogen atom substituents on the antimalarial act. ion of 4-dialkylaminoalkylaminoquino-line compounds. Of all the compounds studied thus far, only the 7-halo derivatives show marked antimalarial activity. It has now been found that the introduction of a second halogen atom in the $ position of th' ...

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