Nucleosides, Nucleotides, and Nucleic Acids

Synthesis of New, Base-Modified PNA Monomers

F Sipos, G Sági

文献索引：Sipos, Ferenc; Sagi, Gyula Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 6-7 p. 681 - 685

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被引用次数: 1

摘要

A number of N-Boc-protected peptide nucleic acids (PNA) monomers containing 5-aryl-and 5-alkynyl-uracil bases have been synthesized using different palladium-catalyzed cross- coupling reactions. Starting from the base-unprotected 5-iodo-uracil PNA monomer, only the Stille couplings were accomplished successfully, while Suzuki couplings with boronic acids containing the same aryl groups failed. During Sonogashira couplings with terminal ...