Colloids and Surfaces B: Biointerfaces 2013-05-01

Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces.

Timmy Fyrner, Thomas Ederth, Daniel Aili, Bo Liedberg, Peter Konradsson

文献索引：Colloids Surf. B Biointerfaces 105 , 187-93, (2013)

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摘要

The ability to produce monomolecular coatings with well-defined structural and functional properties is of key importance in biosensing, drug delivery, and many recently developed applications of nanotechnology. Organic chemistry has proven to be a powerful tool to achieve this in many research areas. Herein, we present the synthesis of three oligo(lactosides) glycosylated in a (1→3) manner, and which are further functionalized with amide-linked short alkanethiol spacers. The oligosaccharides (di-, tetra-, and hexasaccharide) originate from the inexpensive and readily available lactose disaccharide. These thiolated derivatives were immobilized onto gold surfaces, and the thus formed self-assembled monolayers (SAMs) on planar gold were characterized by wettability, ellipsometry and infrared reflection-absorption spectroscopy. Further, the ability of these SAMs to stabilize gold nanoparticles in saline solutions was also demonstrated, indicating that the oligosaccharides may be used as stabilizing agents in gold nanoparticle-based assays.Copyright © 2013 Elsevier B.V. All rights reserved.