Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (−)-epigallocatechin gallate

…, T Minato, T Noguchi-Yachide, M Suganuma…

文献索引：Dodo, Kosuke; Minato, Taro; Noguchi-Yachide, Tomomi; Suganuma, Masami; Hashimoto, Yuichi Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 7975 - 7982

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被引用次数: 39

摘要

Green tea and (−)-epigallocatechin gallate (EGCG: one of the main components of green tea) are reported to have cancer-preventive activity in humans. A previous SAR study of EGCG and derivatives indicated that a galloyl group is essential for the activity. To test this hypothesis, we synthesized various alkyl gallate and gallamide derivatives and evaluated their antiproliferative effects on human leukemia HL-60 cells. Dodecyl 3, 4, 5- ...