Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents

…, K Komatsu, P Bonaz-Krause, Y Zyrianov…

文献索引：Ren, Shijun; Wang, Rubin; Komatsu, Kenichi; Bonaz-Krause, Patricia; Zyrianov, Yegor; McKenna, Charles E.; Csipke, Csaba; Tokes, Zoltan A.; Lien, Eric J. Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 410 - 419

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被引用次数: 265

摘要

Thirty Schiff bases of hydroxysemicarbazide (Ar-CH NNHCONHOH) have been synthesized and tested against L1210 murine leukemia cells. The IC50 values were found to be in a range from 2.7× 10-6 to 9.4× 10-4 M. A total of 17 out of the 30 compounds had higher inhibitory activities than hydroxyurea (an anticancer drug currently used for the treatment of melanoma, leukemia, and ovarian cancer) against L1210 cells. Six compounds with IC50 ...