Bioorganic & Medicinal Chemistry Letters 2001-04-09

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences.

A E Håkansson, J Wengel

文献索引：Bioorg. Med. Chem. Lett. 11 , 935-938, (2001)

摘要

Synthesis of a 9-mer alpha-L-LNA (alpha-L-ribo configured locked nucleic acid) containing three 9-(2-O,4-C-methylene-alpha-L-ribofuranosyl)adenine nucleotide monomer(s) has been accomplished. The work involved synthesis of the bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine followed by C2'-epimerization. Hybridization studies demonstrated very strong duplex formation with 9-mer complementary DNA, RNA, LNA and alpha-L-LNA target sequences.

结构式	名称/CAS号	分子式	全部文献
	N6-苯甲酰基腺嘌呤 CAS:4005-49-6	C₁₂H₉N₅O

Facile synthesis of N-(1-alkenyl) derivatives of 2,4-pyrimid...
2000-07-01
[Nucleosides Nucleotides Nucleic Acids 19 , 1093-1100, (2000)]

Synthesis of oxy-peptide nucleic acids with mixed sequences.
1999-01-01
[Nucleic Acids Symp. Ser. 42 , 31-32, (1999)]

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences.

摘要

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