Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

TJ Donohoe, MA Kabeshov, AH Rathi…

文献索引：Donohoe, Timothy J.; Kabeshov, Mikhail A.; Rathi, Akshat H.; Smith, Ian E. D. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 5 p. 1093 - 1101

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被引用次数: 52

摘要

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenesvia a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.