Il Farmaco

Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V

VLM Sena, RM Srivastava, RO Silva, VLM Lima

文献索引：Sena, Vera L.M.; Srivastava, Rajendra M.; Silva, Ricardo O.; Lima, Vera L.M. Farmaco, 2003 , vol. 58, # 12 p. 1283 - 1288

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被引用次数: 46

摘要

A series of N-aryl-or N-(1, 2, 4-triazol-yl)-phthalimides (4a–4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a–2i). All compounds presented hypolipidemic activity, but compound 4d proved to be the most active and reduced plasma cholesterol and triglyceride levels in Swiss white mice significantly.