Substrate selectivity and orientation in aromatic substitution by molecular fluorine

F Cacace, P Giacomello, AP Wolf

文献索引：Cacace, F.; Giacomello, P.; Wolf, A. P. Journal of the American Chemical Society, 1980 , vol. 102, # 10 p. 3511 - 3515

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被引用次数: 81

摘要

Abstract: Direct elemental fluorination of representative aromatic substrates, including PhH, PhCH3, PhF, PhCI, PhBr, PhN02, PhCN, and PhOCH3, has been investigated in inert solvents, eg, CC13F and other fluorocarbons, over the temperature range-154 to 40 OC. In order to achieve the necessary control of the extremely reactive electrophile, and to minimize unwanted modifications of the reaction environment, the fluorination has been ...