In-vitro Cytotoxic Activities of the Major Bromophenols of the Red Alga Polysiphonia l anosa and Some Novel Synthetic Isomers

…, PA Linley, DJ Swaine, RT Wheelhouse…

文献索引：Shoeib, Nagwa A.; Bibby, Michael C.; Blunden, Gerald; Linley, Peter A.; Swaine, David J.; Wheelhouse, Richard T.; Wright, Colin W. Journal of Natural Products, 2004 , vol. 67, # 9 p. 1445 - 1449

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被引用次数: 48

摘要

Bioassay-guided fractionation was applied to the cytotoxic chloroform fraction of the red alga Polysiphonia lanosa. The major compounds of the most active fraction were identified using GLC-MS analysis as lanosol (1), methyl, ethyl, and n-propyl ethers of lanosol (1a, 1b, and 1c, respectively), and aldehyde of lanosol (2), although 1b appears to be an artifact arising during the fractionation procedure. These compounds and other known bromophenols ...