Atherosclerosis 2013-05-01

Serum amyloid A stimulates lipoprotein-associated phospholipase A2expression invitro and invivo.

Bo Li, Zhe Dong, Hui Liu, Yan-Fei Xia, Xiao-Man Liu, Bei-Bei Luo, Wen-Ke Wang, Bin Li, Fei Gao, Cheng Zhang, Ming-Xiang Zhang, Yun Zhang, Feng-Shuang An

文献索引：Atherosclerosis 228(2) , 370-9, (2013)

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摘要

Although lipoprotein-associated phospholipase A2 (Lp-PLA2) has been regarded as a biomarker and a causative agent for acute coronary events recently, the mechanism of the regulation of Lp-PLA2 has not been fully elucidated yet. This study was aimed to investigate the influence of serum amyloid A (SAA) on the expression of Lp-PLA2 in THP-1 cells and ApoE-deficient (ApoE(-/-)) mice.