Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor

S Ueda, H Terauchi, M Kawasaki, A Yano…

文献索引：Ueda, Shigeo; Terauchi, Hideo; Kawasaki, Motoji; Yano, Akihiro; Ido, Motoharu Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 5 p. 634 - 637

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被引用次数: 17

摘要

Nitric oxide synthase (NOS) has been divided into two major sub-enzymes, ie inducible NOS (iNOS) and constitutive NOS (cNOS). Although nitric oxide (NO) plays an important role as host defense mediator, excessive production of NO by iNOS has been involved in the pathology of many inflammatory diseases. Recently, we reported that the 2-imino-1, 3- oxazolidine (1a) weakly inhibits iNOS and that introduction of an alkyl moiety on the ...