N-Substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl) piperidines

…, G Loew, A Camerman, N Camerman

文献索引：Cheng; Uyeno; Polgar; Toll; Lawson; DeGraw; Loew; Camerman Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 531 - 537

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被引用次数: 20

摘要

I) in order to investigate their opiate receptor binding behavior and opioid agonist and antagonist pharmacological activities. To the best of our knowledge, no other studies have appeared in which the actions of resolved 3-(m-hydroxyphenyl) piperidines have been examined for their in vitro receptor binding and in vivo pharmacological activities. Moreover an X-ray structure determination of one enantiomer,(+)-5, has permitted the determination ...