Biochimica et Biophysica Acta (BBA) - General Subjects 2012-09-01

Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes

Barbara Viljetić, Irena Labak, Senka Majić, Anamaria Štambuk, Marija Heffer, Barbara Viljetić, Irena Labak, Senka Majić, Anamaria Štambuk, Marija Heffer

文献索引：Biochim. Biophys. Acta 1820(9) , 1437-43, (2012)

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摘要

Background Mono-, di- and trisialo gangliosides are major glycosphingolipids in the brain of higher vertebrates involved in lipid raft assembly. In contrast, the fish brain is abundant in polisialo-gangliosides, whose function is implicated in the modulation of repulsive and attractive intercellular interactions during embryonic development and a temperature adaptation process. The histological distribution of gangliosides is usually studied in rodent and mammalian brains, but to date it has not been described in the case of fish brain.