Chemistry Letters

Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl) acetonitrile

Y Kawano, N Kaneko, T Mukaiyama

文献索引：Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki Chemistry Letters, 2005 , vol. 34, # 11 p. 1508 - 1509

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被引用次数: 29

摘要

-Hydroxy nitriles are known as useful building blocks since they may readily be converted to -hydroxycarboxylic acids or -amino alcohols.1 In general, -hydroxy nitriles are prepared by the condensation of carbonyl compounds with alkali acetonitriles that are formed by -deprotonation of nitriles.2 However, the yields of this condensation are not always satisfac- tory because this reaction is a reversible one, and the produced -hydroxy nitrile is dehydrated easily to ...